Better late than never?

نویسنده

  • Keith R McCrae
چکیده

Although additional validation studies are needed, the data suggest that knowledge of circulating miRNAs such as miR-155 may someday be used to predict which patients with MBL go on to develop overt CLL. Importantly, the investigators looked at several types of specimens, including CLL cells and plasma from patients with CLL. Plasma miR-155 was as effective a biomarker as miR-155 isolated from cells. Plasma is easier to work with for routine clinical biomarker screening than cellular material. Plasma has also been shown in a number of studies (reviewed in Cortez et al) to contain tiny microvesicles that package miRNA and other biomolecules. Although the investigators only analyzed a small number of samples, the work demonstrated that microvesicles isolated from the plasma of patients with CLL also contained miR-155. This raises important questions such as what the purpose of miR-155 in secreted microvesicles is, and can they act as hormones, as suggested. Having a plasma-based biomarker to predict which patients will respond to therapy is a Holy Grail of cancer therapeutics. Although future studies will require multicenter trials to evaluate the predictive value of miR-155, the results presented by Ferrajoli et al are very encouraging. Conflict-of-interest disclosure: The author declares no competing financial interests. n

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Better Late Than Never - An Analysis of Last-Minute Travelers Attending a Specialist Travel Medicine Clinic in Ireland

Introduction: Last-minute travelers (LMTs) are a vulnerable group, because it may not be possible to adequately vaccinate them against exposure to infectious diseases. The purpose of this retrospective cross-sectional study was to describe the characteristics of LMTs attending a travel health clinic. Methods: The following data was extracted from records ...

متن کامل

Gene regulation: Better late than never?

A new study has found that, in Arabidopsis, the paternal copies of many genes are delayed in expression during early seed development. The distribution of the genes and nature of their products suggest that this delayed expression of paternal alleles may be a global phenomenon.

متن کامل

Childhood weight, stature, and body mass index among never overweight, early-onset overweight, and late-onset overweight groups.

OBJECTIVE To determine the effects of timing of onset of overweight (OW) on childhood anthropometric adiposity levels using long-term serial data from the Fels Longitudinal Study. CLASSIFICATION OW was defined as body mass index (BMI; kg/m(2)) >25, and the age at first measurement of BMI >25 was the age of onset of OW. Early onset of OW (early-OW) and late onset of OW (late-OW) were defined a...

متن کامل

Better Late than Never: a Study of Late Entrants in Household Electrical Equipment

For the most part, studies on timing of entry have attempted to determine the advantages that early entrants may be able to develop and hold over subsequent entrants. Given that a large number of firms attempt to enter at a much later stage in the development of the market, it is particularly surprising that little research has attempted to examine the differences in the ability of late movers ...

متن کامل

Better Late Than Never: Filling a Void in the History of Fast Matrix Multiplication and Tensor Decompositions

Multilinear and tensor decompositions are a popular tool in linear and multilinear algebra and have a wide range of important applications to modern computing. Our paper of 1972 presented the first nontrivial application of such decompositions to fundamental matrix computations and was also a landmark in the history of the acceleration of matrix multiplication. Published in 1972 in Russian, it ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Blood

دوره 122 11  شماره 

صفحات  -

تاریخ انتشار 2013